Research Article
An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin
Table 15
Summary of gross pathology findings in the 90-day study on curcumin.
| | Gross Pathology observation (s) | Number of animals with or without lesion (s)/ Numbers of animals observed | Vehicle
0 | 250 | 500 | 100 | Ref Item 1000 |
| | Males |
| | No abnormalities detected | 19/20 | 18/20 | 18/20 | 19/20 | 13/20 |
| | Lungs- Discoloration, yellow | 0/20 | 1/20 | 1/20 | 1/20 | 7/20 |
| | Testes- Small sized, unilateral/ bilateral | 1/20 | 0/20 | 1/20 | 0/20 | 0/20 |
| | Epididymides- Small sized, unilateral | 1/20 | 0/20 | 0/20 | 0/20 | 0/20 |
| | Epididymides- Foci, white | 0/20 | 0/20 | 1/20 | 0/20 | 0/20 |
| | Kidneys- Hydronephrosis, unilateral | 0/20 | 1/20 | 0/20 | 0/20 | 0/20 |
| | Kidneys- Cystic, unilateral | 0/20 | 0/20 | 1/20 | 0/20 | 0/20 |
| | Females |
| | No abnormalities detected | 19/20 | 19/20 | 20/20 | 18/20 | 19/20 |
| | Lungs- Discoloration, yellow | 0/20 | 1/20 | 0/20 | 2/20 | 1/20 |
| | Kidneys- Cystic, unilateral | 1/20 | 0/20 | 0/20 | 0/20 | 0/20 |
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