A Toxicological Evaluation of Methylliberine (Dynamine®)

Figure 4

Testes sections of male rats in the 90-day study (H&E, 200X). (a) Normal active spermatogenesis and mature spermatozoa (arrow) in a male control animal at termination of treatment. (b) Decreased intensity of spermatogenesis, degeneration of germ cells, multinucleated giant cell (arrow), and lack of mature spermatozoa in a male animal at 225 mg/kg bw/day at termination of treatment. (c) Normal active spermatogenesis and mature spermatozoa (arrow) in a male animal at 225 mg/kg bw/day at the end of the recovery period. (d) Decreased intensity of spermatogenesis, degeneration of germ cells, and lack of mature spermatozoa in a male animal at 225 mg/kg bw/day at the end of the recovery period.

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