A Toxicological Evaluation of Methylliberine (Dynamine®)

Table 4

Results of the in vivo mammalian micronucleus test.

Groups (^†)	Sampling time (hours following final treatment)	Total number of PCEs analysed	MPCE (per 4000 PCE)		PCE/PCE  +  NCE
			Mean	±SD	Mean	±SD
Historical negative control	24	260000	5.05	1.00	—	—
Concurrent negative control	24	20000	6.20	1.30	0.53	0.02
175 mg/kg bw	24	20000	5.80	1.64	0.52	0.01
350 mg/kg bw	24	20000	6.20	1.30	0.50	0.02
700 mg/kg bw	24	20000	6.80	1.30	0.49	0.01
Positive control (60 mg/kg bw)	24	20000	141.00	5.96	0.39	0.05

^†Historical negative control . to the historical negative control (value was inside in the 95% control limits (2.87–7.23) of the historical control data). to the concurrent and historical negative control.