Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats

Table 2

Liver injury parameters. Values are expressed as M ± SD of 10 animals in each group.

Variables	Control group	HgCl2 group	HgCl2 + DPPD group
Serum:
ALT (U/L)	33.30 ± 3.30	64.70 ± 14.16^a	41.80 ± 11.14^b
AST (U/L)	59.40 ± 5.12	114.70 ± 15.96^a	74.00 ± 5.43^a,b
ALP (U/L)	215.45 ± 5.42	333.97 ± 32.48^a	247.10 ± 25.91^a,b
Homogenate:
Hydroxyproline (ug/mg tissue)	19.80 ± 1.84	39.20 ± 1.77^a	24.36 ± 4.08^a,b
MDA (mmol/g tissue)	81.83 ± 4.58	112.72 ± 10.48^a	81.93 ± 4.02^b
SOD (U/mg protein)	20.99 ± 1.75	14.87 ± 2.65^a	19.94 ± 3.71^b
CAT (mol/min/gm)	1.05 ± 0.10	0.60 ± 0.28^a	0.93 ± 0.13^b
Glutathione (μmol/g protein)	25.35 ± 1.50	18.97 ± 3.10^a	22.24 ± 2.01^a,b
TGF-β (ng/ml)	32.31 ± 2.45	50.60 ± 8.83^a	34.60 ± 4.92^b
CD4 (ng/ml)	24.44 ± 2.64	39.66 ± 1.60^a	25.30 ± 3.31^b
CD8 (ng/ml)	19.73 ± 1.13	38.5 ± 2.88^a	21.07 ± 3.84^b

SD: standard deviation; P : probability; significance <0.05; high significance. The test used was one-way ANOVA followed by post hoc Tukey. ^aSignificance relative to the control group compared with HgCl₂ and HgCl₂ + DPPD groups. ^bSignificance between the HgCl₂ group and HgCl₂ + DPPD group.