A Toxicological Evaluation of Germanium Sesquioxide (Organic Germanium)

Table 10

Summary of macroscopic results, 90-day study.

Organs	Group^‡ mg/kg bw/day	Control	500	1000	2000
	Observations	(# with observation/# observed)
Males	No macroscopic findings	8/10	6/10	9/10	5/10
Thymus	Hemorrhage	0/10	1/10	0/10	0/10
Liver	Congestion	0/10	0/10	0/10	1/10
Kidneys	Cyst	1/10	0/10	0/10	0/10
	Pyelectasia	0/10	1/10	1/10	2/10
Epididymides	Yellow knots on the tail	0/10	1/10	0/10	0/10
Spleen	Formation on the surface	0/10	0/10	0/10	1/10
Cecum	Dilatation	0/10	0/10	0/10	1/10
Skin	Alopecia	1/10	1/10	0/10	0/10
Females	No macroscopic findings	2/10	7/10	5/10	8/10
Lungs	Point-like hemorrhages	1/10	0/10	0/10	0/10
Kidneys	Pyelectasia	2/10	1/10	0/10	0/10
	Hydronephrosis	1/10	0/10	0/10	0/10
Ureter	Dilatation	1/10	0/10	0/10	0/10
Thymus	Hemorrhages	1/10	0/10	1/10	2/10
Uterus	Hydrometra	6/10	3/10	5/10	0/10
Skin	Alopecia	1/10	0/10	0/10	0/10

^‡n = 10 for all groups.