Toxicological Profile of the Aqueous Extract of Tectona grandis L.F. (Verbenaceae) Leaves: A Medicinal Plant Used in the Treatment of Typhoid Fever in Traditional Cameroonian Medicine

Table 6

Effect of aqueous extract of T. grandis leaves on kidney function markers of animals.

Groups	S-Urea (mg/dL)	S-Crea (mg/dL)	U-Urea (mg/dL)	U-Crea (mg/dL)	Urine protein (mg/dL)
Males
Control	73.50 ± 6.75^ab	1.61 ± 0.51^b	4145.83 ± 146.58^a	7.73 ± 0.95^b	0.36 ± 0.09^a
30 mg/kg	62.83 ± 13.84^a	1.44 ± 0.55^b	3591.67 ± 46.39^a	8.33 ± 1.68^b	0.60 ± 0.52^a
90 mg/kg	72.50 ± 8.24^ab	1.11 ± 0.22^ab	2612.50 ± 61.42^a	7.14 ± 0.75^ab	0.43 ± 0.23^a
270 mg/kg	108.92 ± 10.12^c	1.34 ± 0.16^ab	8100.00 ± 115.31^b	5.42 ± 0.88^a	0.71 ± 0.40^a
810 mg/kg	134.58 ± 18.55^d	0.75 ± 0.19^a	12283.33 ± 155.20^c	9.39 ± 1.86^b	0.52 ± 0.37^a
Females
Control	49.42 ± 11.85^a	1.26 ± 0.37^b	4333.33 ± 99.50^b	7.14 ± 1.77^ab	0.37 ± 0.10^a
30 mg/kg	42.33 ± 3.19^a	1.20 ± 0.25^b	3341.67 ± 121.84^ab	6.35 ± 1.99^ab	0.58 ± 0.33^a
90 mg/kg	50.50 ± 5.95^a	0.86 ± 0.20^ab	2812.50 ± 34.35^a	5.75 ± 3.15^ab	0.73 ± 0.44^a
270 mg/kg	81.92 ± 15.04^b	0.99 ± 0.35^ab	4983.33 ± 62.31^b	3.57 ± 0.82^a	0.85 ± 0.11^a
810 mg/kg	95.50 ± 10.99^b	0.63 ± 0.04^a	10158.33 ± 74.65^c	7.67 ± 2.51^b	0.47 ± 0.19^a

Data are expressed as mean ± SD, n = 4. Values for a given group in a column followed by a different letter as superscript are significantly different according to Waller–Duncan’s multiple comparison test ( < 0.05). S-Crea: serum creatinine, U-Crea: urine creatinine, S-Urea: serum urea, U-Urea: urine urea.