Acute and Subchronic Toxicity Studies on the Aqueous Extract of the Plant Mixture (Bidens pilosa and Cymbopogon citratus Aerial Parts) in Rat Model

Table 6

Effects of the plant mixture aqueous extract on the blood elements in females.

Parameters	TN	TSAT	BC 200	BC 400	BC 800	SAT
WBC (10^3/μL)	14.65 ± 1.50	13.36 ± 0.68	9.68 ± 0.79^a	13.70 ± 0.87	13.81 ± 0.34	14.84 ± 0.34
RBC (10^3/μL)	8.43 ± 0.11	8.01 ± 0.21	8.29 ± 0.21	8.45 ± 0.20	7.95 ± 0.23	8.18 ± 0.47
LYM (10^3/μL)	11.46 ± 0.94	9.60 ± 0.81	8.47 ± 1.45	5.23 ± 2.06	8.67 ± 0.76	7.44 ± 1.51
MONO (10^3/μL)	0.36 ± 0.04	0.37 ± 0.01	0.31 ± 0.03	0.35 ± 0.05	0.32 ± 0.09	0.29 ± 0.12
NEUT (10^3/μL)	3.87 ± 0.75	2.93 ± 0.13	2.84 ± 0.80	4.02 ± 0.83	3.31 ± 0.60	3.65 ± 0.25
EO (10 ^3/μL)	0.24 ± 0.06	0.26 ± 0.07	0.24 ± 0.03	0.12 ± 0.02	0.22 ± 0.12	0.17 ± 0.07
BASO (10^3/μL)	0.02 ± 0.01	0.02 ± 0.01	0.01 ± 0.01	0.01 ± 0.01	0.01 ± 0.01	0.01 ± 0.01
HB (g/dL)	14.27 ± 0.27	13.50 ± 0.46	13.90 ± 0.30	14.33 ± 0.43	13.73 ± 0.15	13.43 ± 0.67
PLT (10^3/μL)	853.50 ± 77.50	755.50 ± 59.50	871.00 ± 40.00	951.30 ± 67.98	926.70 ± 30.47	1003 ± 11.50
HCT (%)	51.57 ± 0.80	49.27 ± 1.18	50.50 ± 1.61	52.37 ± 1.02	51.20 ± 1.45	49.13 ± 2.96

Each value represents the mean ± SEM. n = 5. TN: normal rats receiving distilled water (10 mL/kg); TSAT: normal satellite observed 14 more days after stopping every treatment; BC 200, BC 400, and BC 800: animals receiving the aqueous extract of the mixture of B. pilosa and C. citratus at the respective doses of 200, 400, and 800 mg/kg; SAT: satellite extract at the dose of 800 mg/kg observed 14 days after stopping every treatment. WBC: white blood cells; RBC: red blood cells; LYM: lymphocytes; MON: monocytes; NEUT: neutrophils; EO: eosinophils; BASO: basophils; PLT: blood platelets; HB: haemoglobin; HCT: haematocrit. ^a: significant difference from normal controls.