Acute and Subchronic Toxicity Studies on the Aqueous Extract of the Plant Mixture (Bidens pilosa and Cymbopogon citratus Aerial Parts) in Rat Model

Table 7

Effects of the plant mixture aqueous extract on the blood elements in males.

Parameters	TN	TSAT	BC 200	BC 400	BC 800	SAT
WBC (10^3/μL)	12.23 ± 0.87	10.97 ± 0.38	13.05 ± 0.55	15.58 ± 0.85	18.32 ± 1.36^a	13.70 ± 0.94
RBC (10^3/μL)	8.77 ± 0.21	8.75 ± 0.24	8.39 ± 0.42	8.98 ± 0.07	8.57 ± 0.48	9.57 ± 0.17
LYM (10^3/μL)	8.55 ± 0.67	7.01 ± 0.09	8.86 ± 0.69	10.99 ± 0.50	12.65 ± 1.04	12.16 ± 1.11
MONO (10^3/μL)	0.29 ± 0.07	0.40 ± 0.22	0.82 ± 0.15^a	0.61 ± 0.09^a	0.39 ± 0.04	0.35 ± 0.01
NEUT (10^3/μL)	3.29 ± 0.21	3.84 ± 0.67	3.36 ± 0.84	4.22 ± 0.47	4.35 ± 0.68	3.50 ± 0.25
EO (10^3/μL)	0.09 ± 0.01	0.22 ± 0.08	0.04 ± 0.02	0.14 ± 0.04	0.17 ± 0.02	0.22 ± 0.09
BASO (10^3/μL)	0.02 ± 0.01	0.02 ± 0.01	0.01 ± 0.01	0.01 ± 0.01	0.01 ± 0.01	0.01 ± 0.01
HB (g/dL)	15.10 ± 0.11	14.60 ± 0.69	14.60 ± 0.12	14.97 ± 0.28	14.47 ± 0.24	15.73 ± 0.32
PLT (10^3/μL)	816.00 ± 87.00	920.70 ± 46.24	904.30 ± 20.41	869.70 ± 35.35	1023.00 ± 20.50	759.00 ± 83.00
HCT (%)	55.07 ± 1.06	53.30 ± 2.94	55.23 ± 1.19	55.87 ± 1.14	54.53 ± 0.83	57.10 ± 1.22

Each value represents the mean ± SEM. n = 5. TN: normal rats receiving distilled water (10 mL/kg); TSAT: normal satellite observed 14 more days after stopping every treatment; BC 200, BC 400, and BC 800: animals receiving the aqueous extract of the mixture of B. pilosa and C. citratus at the respective doses of 200, 400, and 800 mg/kg; SAT: satellite extract at the dose of 800 mg/kg observed 14 days after stopping every treatment. WBC: white blood cells; RBC: red blood cells; LYM: lymphocytes; MON: monocytes; NEUT: neutrophils; EO: eosinophils; BASO: basophils; PLT: blood platelets; HB: haemoglobin; HCT: haematocrit. ^a: significant difference from normal controls.