Assessment of the Teratogenic Effect of Sulfadoxine-Pyrimethamine on the Chicken Embryo

Table 1

Effect of sulfadoxine-pyrimethamine injection on relative weights (%) of chick and organ.

Batch	Chicks	Chicks without yolk sac	Chicks with yolk sac	Heart	Liver
Control	31.53 ± 1.09	90.85 ± 1.02	3.91 ± 0.85	0.81 ± 0.07	2.85 ± 0.11
NaCl	35.88 ± 0.97	89.25 ± 1.58	7.61 ± 1.08	0.93 ± 0.07	2.71 ± 0.14
SPJ0	28.00 ± 0.69	92.32 ± 0.94	4.60 ± 0.71	0.83 ± 0.07	3.10 ± 0.10
SPJ12	33.78 ± 1.12	89.45 ± 1.81	6.61 ± 1.75	0.92 ± 0.06	3.06 ± 0.07
SPJ14	34.18 ± 0.51	90.23 ± 1.13	6.44 ± 1.06	0.91 ± 0.03	3.11 ± 0.23
SPJ16	32.86 ± 0.87	88.88 ± 2.14	7.94 ± 2.18	0.77 ± 0.06	2.75 ± 0.23
SPJ16-J18	33.34 ± 0.58	87.30 ± 2.04	5.24 ± 0.44	0.75 ± 0.02	2.72 ± 0.08
SPJ18	33.94 ± 0.74	93.42 ± 1.06	4.76 ± 0.59	0.75 ± 0.04	3.14 ± 0.19

Data are expressed as mean ± standard error of the mean (SEM) and analyzed by one-way ANOVA, followed by Tukey test () as compared to the respective parameter value of control groups. SP_J0 = injection of sulfadoxine-pyrimethamine before the start of incubation; SP_J12 = injection of sulfadoxine-pyrimethamine on day 12 of incubation; SP_J14 = injection of sulfadoxine-pyrimethamine on day 14 of incubation; SP_J16 = injection of sulfadoxine-pyrimethamine on day 16 of incubation; SP_J16-J18 = injection of sulfadoxine-pyrimethamine on day 16 and day 18 of incubation; SP_J18 = injection of sulfadoxine-pyrimethamine on day 18 of incubation.