Assessment of the Teratogenic Effect of Sulfadoxine-Pyrimethamine on the Chicken Embryo

Table 3

Effect of sulfadoxine-pyrimethamine combination on hematological parameters of chicks.

Parameters	Control	NaCl	SPJ0	SPJ12	SPJ14	SPJ16	SPJ16-J18	SPJ8
WB (10^3/l)	152.70 ± 3.24	160.35 ± 4.09	165.37 ± 1.75	168.25 ± 2.84	148.64 ± 5.14	160.20 ± 3.29	155.74 ± 6.30	158.20 ± 3.80
Hb (g/dL)	11.63 ± 0.75	12.72 ± 0.67	13.87 ± 0.18	12.85 ± 0.96	11.63 ± 0.54	13.13 ± 0.46	12.53 ± 0.88	13.25 ± 0.57
RB (10^6/uL)	2.17 ± 0.14	2.38 ± 0.07	2.70 ± 0.05	2.30 ± 0.42	2.13 ± 0.09	2.45 ± 0.06	2.36 ± 0.13	2.62 ± 0.09
Hte (%)	31.72 ± 2.17	34.93 ± 1.46	38.88 ± 0.62	34.03 ± 4.82	30.90 ± 1.37	35.47 ± 0.87	33.78 ± 1.97	36.93 ± 1.34
MCV (fL)	146.10 ± 1.16	146.87 ± 2.93	144.32 ± 1.11	154.40 ± 11.16	145.45 ± 1.27	145.00 ± 1.49	143.02 ± 1.39	141.22 ± 1.47
MCH (pg)	53.60 ± 1.05	53.35 ± 1.94	51.38 ± 0.34	60.25 ± 12.64	54.70 ± 1.50	53.53 ± 0.98	52.75 ± 1.34	50.57 ± 1.04
MCHC (g/dL)	36.73 ± 10.78	36.28 ± 0.70	35.62 ± 0.25	39.48 ± 4.23	37.63 ± 0.82	38.62 ± 1.19	36.92 ± 0.72	35.78 ± 0.47
PLT 10³/UL	20.00 ± 3.81	20.20 ± 0.80	24.75 ± 3.25	25.33 ± 2.73	29.00 ± 2.92	16.00 ± 0.91	33.80 ± 2.22	26.75 ± 3.45

Data are expressed as mean ± standard error of the mean (SEM) and analyzed by one-way ANOVA, followed by Tukey test () as compared to the respective parameter value of control groups. GB = white blood cells; NR = red blood cells; Hb = hemoglobin; Hte = hematocrit; MCV = average globular volume; MCH = average corpuscular hemoglobin content; MCHC = mean corpuscular hemoglobin concentration; PLT = platelets. SP_J0 = injection of sulfadoxine-pyrimethamine before the start of incubation; SP_J12 = injection of sulfadoxine-pyrimethamine on day 12 of incubation; SP_J14 = injection of sulfadoxine-pyrimethamine on day 14 of incubation; SP_J16 = injection of sulfadoxine-pyrimethamine on day 16 of incubation; SP_J16-J18 = injection of sulfadoxine-pyrimethamine on day 16 and day 18 of incubation; SP_J18 = injection of sulfadoxine-pyrimethamine on day 18 of incubation.