In Vitro and In Vivo Toxicological Evaluation of Avicennia africana P: Beauv. (Avicenniaceae) Leaf Extract in a Rat Model
Table 1
Haematological indices in animals orally treated with the AAE in the subacute toxicity tests.
Haematological indices (MGKG−1)
Parameters
Control
100
300
1000
value
RBC(M/μL)
8.72 ± 1.15
7.97 ± 0.46
7.84 ± 0.97
7.54 ± 0.12
0.832
HGB (g/dl)
16.10 ± 1.55
13.97 ± 0.68
13.77 ± 1.08
13.65 ± 0.25
0.537
HCT (%)
42.77 ± 4.71
36.97 ± 0.68
39.10 ± 3.98
35.30 ± 0.00
0.532
MCV (FL)
49.40 ± 1.76
46.47 ± 0.86
50.47 ± 4.19
46.90 ± 0.80
0.605
MCH (PG)
18.63 ± 1.09
17.50 ± 0.38
17.73 ± 0.81
18.05 ± 0.65
0.704
MCHC(G/DL)
37.67 ± 0.67
37.67 ± 0.33
35.33 ± 2.40
38.50 ± 0.50
0.270
RDW (%)
13.30 ± 0.24
12.93 ± 0.88
14.07 ± 1.29
12.60 ± 0.50
0.793
PLTX102 (K/μL)
1.27 ± 94.50
1.56 ± 248.80
1.43 ± 200.32
1.69 ± 41.50
0.484
MPV (FL)
4.27 ± 0.15
3.73 ± 0.09
4.30 ± 0.17
3.85 ± 0.25
0.119
PDW (FL)
6.70 ± 0.32
6.80 ± 0.56
5.93 ± 1.07
7.15 ± 0.35
0.481
WBC (K/μL)
6.43 ± 1.25
8.32 ± 0.77
2.99 ± 1.49
8.31 ± 2.50
0.062
LYM (%)
48.55 ± 3.66
25.48 ± 5.21a,b
26.91 ± 7.26a,b
48.04 ± 8.85
0.031
MON (%)
5.62 ± 1.78
5.09 ± 0.49
4.63 ± 1.58
9.04 ± 0.35
0.082
NEU (%)
41.49 ± 3.27
65.47 ± 5.7a,b
64.91 ± 7.63a,b
37.51 ± 4.29
0.002
EOS (%)
3.87 ± 0.80
3.73 ± 1.05
1.32 ± 0.56
5.05 ± 4.19
0.563
BASO (%)
0.47 ± 0.07
0.23 ± 0.09
0.20 ± 0.17
0.36 ± 0.02
0.217
One-way ANOVA with Tukey’s multiple comparison tests was used to analyze the data. The values represent the mean ± S.E.M. (n = 5) (14 days) The letters (a) indicate a statistically significant difference between the control and treatment groups; the letters (b) indicate a statistically significant difference between the 1000, 100, and 300 mgkg−1 groups.
