In Vitro and In Vivo Toxicological Evaluation of Avicennia africana P: Beauv. (Avicenniaceae) Leaf Extract in a Rat Model

Table 2

Serum biochemical indices in animals orally dosed with the AAE in the subacute toxicity tests.

Biochemical Values (mgkg^−1)
Parameters	Control	100	300	1000	value
AST (U/L)	92.80 ± 3.66	86.68 ± 11.78	92.90 ± 3.95	96.30 ± 2.40	0.581
ALT (U/L)	50.52 ± 3.88	47.45 ± 2.79	53.51 ± 7.46	44.81 ± 11.41	0.395
ALP (U/L)	36.13 ± 9.57	57.67 ± 4.98	43.67 ± 3.99	55.35 ± 6.45	0.169
TP (g/L)	63.40 ± 4.58	64.63 ± 4.11	65.73 ± 4.00	65.00 ± 2.65	0.217
ALB (g/L)	28.53 ± 1.42	28.83 ± 0.94	31.93 ± 2.78	33.20 ± 0.50	0.378
GLB (g/L)	34.87 ± 3.83	34.67 ± 4.49	38.17 ± 1.93	43.45 ± 2.15	0.502
A/G	0.84 ± 0.10	0.85 ± 0.10	0.84 ± 0.09	0.77 ± 0.03	0.616
TB (μmol/L)	5.87 ± 1.41	3.87 ± 0.26	4.17 ± 0.52	3.35 ± 0.05	0.148
DB (μmol/L)	1.70 ± 0.70	1.80 ± 0.15	1.83 ± 0.29	1.20 ± 0.50	0.792
IDB (μmol/L)	4.17 ± 1.00	2.07 ± 0.28	2.33 ± 0.79	2.15 ± 0.45	0.140
CRE (μmol/L)	80.60 ± 18.41	62.58 ± 5.28	54.40 ± 5.15	65.72 ± 12.25	0.320
Urea (mmol/L)	6.43 ± 0.42	6.30 ± 0.81	5.37 ± 0.97	6.55 ± 0.45	0.856
Ca (mmol/L)	2.33 ± 0.04	2.38 ± 0.03	2.58 ± 0.06	2.37 ± 0.05	0.353
Trig (mmol/L)	0.91 ± 0.08	0.89 ± 0.03	0.87 ± 0.01	1.08 ± 0.13	0.343
Tchol (mmol/L)	1.63 ± 0.14	1.93 ± 0.38	2.03 ± 0.01	1.99 ± 0.08	0.752
HDL_C (mmol/L)	0.63 ± 0.05	0.46 ± 0.24	0.74 ± 0.11	0.90 ± 0.10	0.324
LDL_C (mmol/L)	0.58 ± 0.13	1.06 ± 0.61	0.89 ± 0.12	0.60 ± 0.08	0.792
VLDL_C (mmol/L)	0.42 ± 0.03	0.41 ± 0.01	0.40 ± 0.01	0.49 ± 0.06	0.398

Data analysed using one-way ANOVA with Tukey’s multiple comparison test. Values represent mean ± S.E.M. (n = 5) (14 days).