Toxicological Assessments of a Proprietary Blend of Punica granatum Fruit Rind and Theobroma cacao Seed Extracts: Acute, Subchronic, and Genetic Toxicity Studies

Table 1

Effect of 90-day oral administration of LN18178 on the body weights of male and female Wistar rats.

Day	Sex	LN18178 dose (mg/kg·BW)
		Main groups				Reversal groups
		0	625	1250	2500	0	2500
Predose	M	166.75 ± 12.55	171.25 ± 16.34	168.01 ± 9.50	167.91 ± 17.14	165.86 ± 11.6	163.74 ± 7.18
	F	141.19 ± 8.15	141.64 ± 8.33	140.57 ± 6.03	142.17 ± 7.23	136.2 ± 8.81	134.97 ± 10.37
28	M	285.94 ± 23.68	290.09 ± 19.01	294.93 ± 31.15	287.31 ± 26.16	300.11 ± 23.12	308.34 ± 17.42
	F	194.84 ± 12.16	193.16 ± 13.54	199.09 ± 11.19	194.63 ± 17.4	197.15 ± 7.31	196.44 ± 14.66
56	M	343.72 ± 38.66	342.87 ± 24.01	345.63 ± 39.79	337.59 ± 32.12	354.96 ± 30.64	351.76 ± 24.27
	F	213.90 ± 13.90	210.21 ± 15.19	219.31 ± 16.75	212.69 ± 23.13	217.68 ± 10.03	214.27 ± 21.31
84	M	372.66 ± 44.86	375.14 ± 23.28	374.66 ± 42.23	373.25 ± 33.77	386.13 ± 32.16	382.56 ± 22.64
	F	228.78 ± 12.98	225.45 ± 19.02	227.51 ± 16.12	226.53 ± 23.91	232.27 ± 14.31	231.7 ± 17.23
91	M	379.28 ± 46.31	382.28 ± 23.81	382.19 ± 40.82	377.74 ± 32.30	389.51 ± 31.39	384.88 ± 23.5
	F	230.63 ± 13.99	227.04 ± 18.53	229.14 ± 15.68	228.45 ± 23.48	235.37 ± 14.41	233.55 ± 16.62
118	M	—	—	—	—	417.73 ± 33.09	412.2 ± 31.23
	F	—	—	—	—	248.04 ± 13.36	245.94 ± 7.51

Data are presented as mean ± SD of body weight (BW) in . n = 20 in main groups (10 males and 10 females) and n = 10 in reversal groups (5 males and 5 females).