Toxicological Assessments of a Proprietary Blend of Punica granatum Fruit Rind and Theobroma cacao Seed Extracts: Acute, Subchronic, and Genetic Toxicity Studies

Table 10

Observations on chromosomal aberration induced by LN18178.

Treatments	Concn. (μg/mL)	Number of cells scored	Number of structural aberrant cells without gap
			−S9		+S9
			4 h	22 h	4 h
DMSO^a	0	300	6	2	2
	250	300	—	2	4
LN18178	500	300	3	2	2
	1000	300	1	3	2
	2000	300	4	—	—
Mitomycin C^b	0.3	300	33	37	—
Cyclophosphamide^b	10	300	—	—	28

^aDMSO, dimethylsulfoxide; vehicle control, ^bpositive controls. indicates significant changes () compared with the vehicle control.