Toxicological Assessments of a Proprietary Blend of Punica granatum Fruit Rind and Theobroma cacao Seed Extracts: Acute, Subchronic, and Genetic Toxicity Studies

Table 11

Micronucleated polychromatic erythrocytes (MNPCEs) in LN18178-treated mice bone marrow.

Treatments	Dose (mg/kg.BW)	Number of mice	PCE/TE	% Reduction	% MNPCE
Vehicle control^a	0	10	46.3	—	0.10 ± 0.07
	500	10	46.2	0.2	0.11 ± 0.05
LN18178	1000	10	46.8	−1.1	0.07 ± 0.06
	2000	10	46.3	0	0.07 ± 0.06
Cyclophosphamide^b	40	10	41.2	11.2	1.48 ± 0.19

indicates significant changes () compared with the vehicle control. ^aDistilled water, ^bpositive control; BW, body weight; MNPCE, micronucleated polychromatic erythrocyte; PCE, polychromatic erythrocyte; TE, total erythrocytes. Each group contains 10 animals (5 male and 5 female).