Toxicological Assessments of a Proprietary Blend of Punica granatum Fruit Rind and Theobroma cacao Seed Extracts: Acute, Subchronic, and Genetic Toxicity Studies

Table 2

Effect of 90-day oral administration of LN18178 on food consumption by the male and female Wistar rats.

Day	Sex	LN18178 dose (mg/kg BW)
		Main groups (n = 10)				Reversal groups (n = 5)
		0	625	1250	2500	0	2500
1–28	M	569.72 ± 11.22	561.58 ± 32.82	567.08 ± 20.37	557.12 ± 16.76	583.35 ± 29.81	600.59 ± 48.34
	F	409.25 ± 20.98	397.91 ± 34.70	424.70 ± 22.53	408.33 ± 36.03	406.94 ± 1.97	401.87 ± 3.30
29–56	M	573.96 ± 7.68	561.10 ± 17.92	572.30 ± 14.53	579.39 ± 24.80	585.00 ± 40.78	600.59 ± 3.27
	F	397.95 ± 15.95	384.30 ± 25.07	406.68 ± 14.75	405.36 ± 35.61	402.66 ± 8.04	393.76 ± 5.39
57–90	M	664.16 ± 11.12	658.03 ± 17.16	658.05 ± 14.96	655.55 ± 39.59	700.68 ± 17.47	702.07 ± 21.83
	F	475.25 ± 20.07	473.43 ± 31.39	477.55 ± 10.56	478.88 ± 27.76	497.61 ± 9.28	489.33 ± 10.70
91–118	M	—	—	—	—	538.18 ± 10.91	528.25 ± 11.73
	F	—	—	—	—	370.78 ± 16.49	373.26 ± 33.81

Data are presented as mean ± SD of food consumption in . Each main group contains 20 rats (10 males and 10 females), and reversal group contains 10 rats (5 males and 5 females). BW, body weight; M, male; F, female.