Toxicological Assessments of a Proprietary Blend of Punica granatum Fruit Rind and Theobroma cacao Seed Extracts: Acute, Subchronic, and Genetic Toxicity Studies
Table 5
Effect of 90-day oral administration of LN18178 on the absolute and relative organ weights of male Wistar rats.
Organs
LN18178 dose (mg/kg·BW)
Main groups (n = 10)
Reversal groups (n = 5)
0
625
1250
2500
0
2500
Liver (g)
10.17 ± 1.07
9.89 ± 1.22
9.93 ± 1.21
9.46 ± 1.48
11.45 ± 1.42
11.39 ± 1.27
% of BW
2.78 ± 0.39
2.65 ± 0.27
2.66 ± 0.10
2.56 ± 0.23
2.83 ± 0.44
2.84 ± 0.14
Kidneys (g)
2.35 ± 0.23
2.22 ± 0.29
2.31 ± 0.24
2.36 ± 0.30
2.56 ± 0.32
2.69 ± 0.33
% of BW
0.64 ± 0.05
0.60 ± 0.06
0.62 ± 0.03
0.64 ± 0.06
0.63 ± 0.08
0.67 ± 0.08
Adrenal glands (g)
0.06 ± 0.01
0.06 ± 0.01
0.06 ± 0.01
0.06 ± 0.01
0.05 ± 0.01
0.06 ± 0.00
% of BW
0.02 ± 0.00
0.02 ± 0.00
0.02 ± 0.00
0.02 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
Heart (g)
1.06 ± 0.14
1.08 ± 0.10
1.11 ± 0.10
1.15 ± 0.23
1.21 ± 0.10
1.17 ± 0.08
% of BW
0.29 ± 0.02
0.29 ± 0.02
0.29 ± 0.03
0.31 ± 0.05
0.30 ± 0.03
0.29 ± 0.01
Brain (g)
2.04 ± 0.09
2.00 ± 0.10
2.08 ± 0.19
2.06 ± 0.12
2.01 ± 0.07
2.05 ± 0.16
% of BW
0.56 ± 0.06
0.54 ± 0.03
0.56 ± 0.04
0.56 ± 0.06
0.50 ± 0.03
0.51 ± 0.05
Spleen (g)
0.69 ± 0.11
0.69 ± 0.08
0.64 ± 0.08
0.71 ± 0.12
0.75 ± 0.05
0.72 ± 0.06
% of BW
0.19 ± 0.05
0.19 ± 0.02
0.17 ± 0.02
0.19 ± 0.03
0.19 ± 0.02
0.18 ± 0.02
Thymus (g)
0.42 ± 0.08
0.41 ± 0.06
0.39 ± 0.07
0.44 ± 0.10
0.37 ± 0.03
0.32 ± 0.05
% of BW
0.11 ± 0.02
0.11 ± 0.01
0.10 ± 0.01
0.12 ± 0.03
0.09 ± 0.01
0.08 ± 0.01
Testes (g)
3.72 ± 0.58
3.56 ± 0.30
3.70 ± 0.38
3.58 ± 0.31
3.59 ± 0.18
3.77 ± 0.24
% of BW
1.01 ± 0.14
0.96 ± 0.07
1.00 ± 0.08
1.13 ± 0.50
0.89 ± 0.11
0.94 ± 0.10
Epididymis (g)
1.45 ± 0.10
1.40 ± 0.12
1.45 ± 0.18
1.46 ± 0.15
1.56 ± 0.14
1.68 ± 0.16
% of BW
0.40 ± 0.04
0.38 ± 0.02
0.39 ± 0.03
0.40 ± 0.03
0.39 ± 0.05
0.42 ± 0.03
SV-CG and prostate gland (g)
2.98 ± 0.55
2.78 ± 0.35
2.87 ± 0.34
2.93 ± 0.30
2.96 ± 0.30
3.05 ± 0.52
% of BW
0.81 ± 0.11
0.75 ± 0.08
0.78 ± 0.11
0.80 ± 0.08
0.73 ± 0.08
0.78 ± 0.19
Thyroid with parathyroid (g)
0.04 ± 0.02
0.03 ± 0.01
0.02 ± 0.01
0.02 ± 0.00
0.05 ± 0.02
0.06 ± 0.02
% of BW
0.01 ± 0.01
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
Pituitary gland (g)
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
% of BW
0.00 ± 0.00
0.00 ± 0.00
0.00 ± 0.00
0.00 ± 0.00
0.00 ± 0.00
0.00 ± 0.00
Data are presented as mean ± SD. indicates significant changes () compared with the control group. BW, body weight; SV-CG, seminal vesicle and coagulating gland.
