Toxicological Assessments of a Proprietary Blend of Punica granatum Fruit Rind and Theobroma cacao Seed Extracts: Acute, Subchronic, and Genetic Toxicity Studies
Table 6
Effect of 90-day oral administration of LN18178 on the absolute and relative organ weights of female Wistar rats.
Organs
LN18178 dose (mg/kg BW)
Main groups (n = 10)
Reversal groups (n = 5)
0
625
1250
2500
0
2500
Liver (g)
6.23 ± 0.51
6.41 ± 0.87
6.67 ± 0.57
6.74 ± 0.62
6.81 ± 0.97
7.39 ± 0.55
% of BW
2.76 ± 0.19
2.88 ± 0.37
2.97 ± 0.19
3.01 ± 0.20
2.80 ± 0.38
3.06 ± 0.28
Kidneys (g)
1.48 ± 0.10
1.40 ± 0.14
1.51 ± 0.14
1.49 ± 0.14
1.66 ± 0.08
1.74 ± 0.17
% of BW
0.67 ± 0.03
0.63 ± 0.04
0.67 ± 0.04
0.67 ± 0.05
0.68 ± 0.06
0.72 ± 0.09
Adrenals (g)
0.08 ± 0.01
0.07 ± 0.01
0.16 ± 0.24
0.08 ± 0.02
0.06 ± 0.00
0.07 ± 0.01
% of BW
0.04 ± 0.00
0.03 ± 0.00
0.07 ± 0.11
0.04 ± 0.01
0.03 ± 0.00
0.03 ± 0.00
Heart (g)
0.73 ± 0.07
0.70 ± 0.04
0.75 ± 0.06
0.77 ± 0.09
0.82 ± 0.03
0.82 ± 0.14
% of BW
0.32 ± 0.03
0.32 ± 0.01
0.33 ± 0.01
0.34 ± 0.03
0.33 ± 0.03
0.34 ± 0.06
Brain (g)
1.90 ± 0.08
1.87 ± 0.12
1.89 ± 0.11
1.90 ± 0.15
1.82 ± 0.10
1.89 ± 0.21
% of BW
0.85 ± 0.05
0.84 ± 0.07
0.84 ± 0.06
0.85 ± 0.09
0.75 ± 0.06
0.78 ± 0.07
Spleen (g)
0.50 ± 0.06
0.49 ± 0.06
0.54 ± 0.08
0.49 ± 0.06
0.53 ± 0.03
0.57 ± 0.09
% of BW
0.22 ± 0.03
0.22 ± 0.03
0.24 ± 0.02
0.18 ± 0.03
0.22 ± 0.01
0.24 ± 0.04
Thymus (g)
0.38 ± 0.07
0.34 ± 0.04
0.35 ± 0.09
0.36 ± 0.08
0.28 ± 0.04
0.33 ± 0.04
% of BW
0.17 ± 0.04
0.15 ± 0.01
0.16 ± 0.04
0.16 ± 0.02
0.12 ± 0.02
0.14 ± 0.02
Uterus with cervix
0.65 ± 0.20
0.64 ± 0.17
0.67 ± 0.17
0.83 ± 0.28
0.66 ± 0.18
0.75 ± 0.21
% of BW
0.29 ± 0.09
0.29 ± 0.08
0.30 ± 0.08
0.38 ± 0.14
0.27 ± 0.09
0.31 ± 0.09
Ovaries (g)
0.17 ± 0.05
0.21 ± 0.10
0.18 ± 0.03
0.15 ± 0.04
0.15 ± 0.04
0.17 ± 0.03
% of BW
0.08 ± 0.02
0.10 ± 0.04
0.08 ± 0.02
0.07 ± 0.02
0.06 ± 0.01
0.07 ± 0.01
Thyroid with parathyroid (g)
0.02 ± 0.01
0.02 ± 0.01
0.02 ± 0.00
0.02 ± 0.00
0.02 ± 0.00
0.03 ± 0.00
% of BW
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
Pituitary (g)
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
% of BW
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
0.00 ± 0.00
0.00 ± 0.00
Data are presented as mean ± SD. indicates significant changes () compared with the control group. BW, body weight.
