Toxicological Assessments of a Proprietary Blend of Punica granatum Fruit Rind and Theobroma cacao Seed Extracts: Acute, Subchronic, and Genetic Toxicity Studies

Table 7

Effect of 90-day oral administration of LN18178 on hormones in male and female Wistar rats.

Measurements	Sex	LN18178 dose (mg/kg·BW)
		Main groups (n = 20)				Reversal groups (n = 10)
		0	625	1250	2500	0	2500
T3 (ng/mL)	M	0.42 ± 0.09	0.34 ± 0.07	0.44 ± 0.10	0.40 ± 0.06	0.36 ± 0.11	0.38 ± 0.15
	F	0.39 ± 0.05	0.43 ± 0.09	0.33 ± 0.06	0.44 ± 0.09	0.41 ± 0.07	0.44 ± 0.14
T4 (μg/dL)	M	4.00 ± 0.60	3.62 ± 0.57	3.62 ± 0.54	4.36 ± 0.73	4.20 ± 0.38	4.43 ± 0.70
	F	3.11 ± 0.61	2.74 ± 0.74	3.43 ± 0.77	2.99 ± 0.39	3.46 ± 0.42	3.11 ± 0.32
TSH (ng/mL)	M	1.63 ± 0.22	1.62 ± 0.24	1.57 ± 0.19	1.55 ± 0.17	1.71 ± 0.33	1.62 ± 0.27
	F	1.62 ± 0.19	1.62 ± 0.18	1.56 ± 0.18	1.64 ± 0.26	1.70 ± 0.38	1.65 ± 0.26

Data are presented as mean ± SD. T3, triiodothyronine; T4, thyroxine; TSH, thyroid-stimulating hormone. Each main group (n = 20; 10 male and 10 female rats); each reversal group (n = 10; 5 male and 5 female rats).