Toxicological Assessments of a Proprietary Blend of Punica granatum Fruit Rind and Theobroma cacao Seed Extracts: Acute, Subchronic, and Genetic Toxicity Studies

Table 8

Summary of histopathological changes in the vital organs of the male and female rats after 90-day oral administration of LN18178.

Organs	Pathological observations	Dose (mg/kg/day BW)
		0	2500	0	2500
		Male (n = 10)		Female (n = 10)
Adrenal glands	Hemorrhage, zona fasciculata	0	0	1 (++)	0
Eyes	Hyperplasia, retina	0	0	1 (+)	0
	Folds, retina	0	0	0	1 (++)
Lungs	Hemorrhage, alveolar	1 (++)	1 (+)	1 (++)	0
	Pigmented macrophage	0	2 (+)	0	0
Stomach	Increased mucosa-associated lymphoid tissue	0	0	1 (+)	0
Duodenum	Yellow pigment	0	1(+)	0	0
Liver	Necrosis	1 (++)	0	0	0
Kidneys	Lymphocyte infiltrate, cortex	1 (++)	1 (++)	0	0
Mesenteric lymph nodes	Pigmented macrophage	0	1 (++)	0	0
Testes	Inflammation	1 (++)	1 (++)	—	—
Epididymis	Inflammation	1 (+)	1 (+++)	—	—

The scores in parentheses +, ++, and +++ indicates minimal, mild, and marked effects, respectively; BW, body weight.