Prenatal Developmental Toxicity and Histopathological Changes of the Placenta Induced by Syzygium guineense Leaf Extract in Rats

Table 1

Maternal weight gain and food intake of pregnant rats treated with 70% ethanol leaf extract of Syzygium guineense.

Weight gain and food intake	Group
	Group I 250 mg/kg	Group II 500 mg/kg	Group III 1000 mg/kg	Group IV control	Group V Ad- libitum control
Food intake/day (g) n = 10	199.2 ± 4.5	191.4 ± 8.0	180.0 ± 12.1!	196.6 ± 10.0	214.0 ± 4.5
Maternal weight gain/dam (g)
Day 6–12	17.8 ± 8.5	17.2 ± 7.4	15.8 ± 7.5	19.0 ± 12.5	40.2 ± 5.8
Day 13–20	69.7 ± 3.4	67.2 ± 6.6	60.5 ± 5.6	72.2 ± 5.6	72.8 ± 9.6

The results are expressed as mean ± SDM, significant difference with all the other groups, ! significant difference with Group I, IV and V, significant difference with group V, significant difference with group IV and V (for all value <0.05); and one-way ANOVA.