Quercetin Zinc and Iron Metal Complexes Protect against Sodium Arsenite Intoxication in the Hepato-Renal System of Wistar Rats via the Oxidative Stress Pathway

Figure 5

(a) Quercetin and its metal complexes increased glutathione-S-transferase in the liver and kidney of sodium-arsenite induced intoxicated rats. (b) Quercetin and its metal complexes normalized CAT activity in the liver and kidney of sodium-arsenite intoxicated rats. (c) Quercetin and its metal complexes increased glutathione concentration in the liver and kidney of sodium arsenate intoxicated rats. (d) Quercetin and its metal complexes inhibited lipid peroxidation in the liver and kidney of sodium arsenite intoxicated rats. Data are presented as the mean ± SD,  = values differ significantly from untreated sodium arsenite-intoxicated rats (), ^# = values differ significantly from normal control rats (), normal control, NaAr-induced toxicity = rats administered sodium arsenite and left untreated, NaAr + Quer = rats administered sodium arsenite and treated with 30 mg/kg quercetin, NaAr + Quer-Zn = rats administered sodium arsenite and treated with 30 mg/kg quercetin-zinc, and NaAr + Quer-Fe = rats administered sodium arsenite and treated with 30 mg/kg quercetin-iron.

(a)

(b)

(c)

(d)