Acute and Repeated Dose 28-Day Oral Toxicity Study of the Aqueous Extracts from the Leafy Stem and Fruit of Pedalium murex D.Royen EX.L in Wistar Rats

Table 5

Relative organ weights (%) of rats after 28 days of treatment with the aqueous extracts of P. murex leafy stem (LS) and fruit (FR).

Organs	Control	LS200	LS400	LS800	FR200	FR400	FR800
Liver	3.83 ± 0.06	3.95 ± 0.18	3.96 ± 0.20	3.68 ± 0.06	3.76 ± 0.12	3.92 ± 0.28	3.51 ± 0.07
Kidneys	0.34 ± 0.01	0.39 ± 0.01	0.42 ± 0.02	0.32 ± 0.01	0.35 ± 0.01	0.41 ± 0.03	0.37 ± 0.01
Heart	0.35 ± 0.01	0.41 ± 0.01	0.38 ± 0.01	0.32 ± 0.01	0.37 ± 0.03	0.43 ± 0.03	0.39 ± 0.02
Spleen	0.36 ± 0.00	0.42 ± 0.03	0.38 ± 0.01	0.33 ± 0.03	0.40 ± 0.01	0.37 ± 0.02	0.35 ± 0.02
Testis	0.56 ± 0.03	0.61 ± 0.04	0.60 ± 0.26	0.64 ± 0.02	0.59 ± 0.29	0.67 ± 0.01	0.63 ± 0.01
Epididymis	0.33 ± 0.02	0.30 ± 0.01	0.33 ± 0.01	0.31 ± 0.01	0.33 ± 0.02	0.40 ± 0.02	0.34 ± 0.02

Values are expressed as the mean ± SEM. value was considered significant using ANOVA followed by Dunett’s multiple comparison test. Asterisk denotes difference compared with the control group.