Acute and Repeated Dose 28-Day Oral Toxicity Study of the Aqueous Extracts from the Leafy Stem and Fruit of Pedalium murex D.Royen EX.L in Wistar Rats

Table 6

Urinalysis of rats after 28 days of treatment with aqueous extracts of P. murex leafy stem (LS) and fruit (FR).

Parameters	Groups
	Control	LS200	LS400	LS800	FR200	FR400	FR800
Occult blood (RBC/µL)
Neg	5	5	5	5	4	0	1
10	0	0	0	0	1	1	1
50	0	0	0	0	0	4	3
Urobilinogen
Neg	5	5	5	5	5	5	5
+	0	0	0	0	0	0	0
++	0	0	0	0	0	0	0
Ketone body
Neg	5	5	5	5	5	5	5
15	0	0	0	0	0	0	0
Glucose (mg/dL)
Neg	5	5	5	5	5	5	5
50	0	0	0	0	0	0	0
1000	0	0	0	0	0	0	0
Proteins (mg/dL)
Neg	5	5	0	0	3	1	0
30	0	0	1	0	1	0	0
100	0	0	1	1	1	3	1
300	0	0	3	4	0	1	4
Nitrite
Neg	5	3	4	5	3	5	4
Pos	0	2	1	0	2	0	1
Leukocytes
Neg	4	5	1	0	5	5	4
25	1	0	3	1	0	0	1
70	0	0	1	4	0	0	0
pH
8	4	5	2	1	4	3	1
9	1	0	3	4	1	2	4
Specific gravity
1.000	3	4	5	5	5	1	0
1.005	0	0	0	0	0	3	0
1.010	2	1	0	0	0	1	5
Volume (ml/24 h)^a	5.38 ± 0.24	5.08 ± 0.25	5.22 ± 0.45	4.82 ± 0.45	5.02 ± 0.28	5.72 ± 0.22	5.70 ± 0.39

Values are expressed as the mean ± SEM. ^aindicates the mean volume of the urine collected for each group. Asterisk denotes significant difference with control group.