Acute and Repeated Dose 28-Day Oral Toxicity Study of the Aqueous Extracts from the Leafy Stem and Fruit of Pedalium murex D.Royen EX.L in Wistar Rats
Table 7
Biochemical parameters of rats after 28 days of treatment with aqueous extracts of P. murex leafy stem (LS) and fruit (FR).
Parameters
Control
LS200
LS400
LS800
FR200
FR400
FR800
AST (UI/L)
137.4 ± 4.24
124±9.73
215.6±4.99
134.9 ± 6.20
117.6±3.17
127.2 ± 3.45
131.4 ± 4.66
ALT (UI/L)
65.4 ± 1.63
65.2 ± 5.77
94.9±9.46
96±9.04
80.2±5.03
54 ± 3.61
59.6 ± 4.96
Glucose (mmol/L)
6.40 ± 0.18
5.14±0.16
4.98±0.24
4.67±0.34
5.97 ± 0.11
6.20 ± 0.28
5.57 ± 0.20
Triglycerides (mmol/L)
0.55 ± 0.06
0.46 ± 0.04
0.86±0.06
0.75 ± 0.12
0.53 ± 0.06
0.74 ± 0.08
0.94±0.06
Total cholesterol (mmol/L)
1.50 ± 0.11
1.91 ± 0.06
1.95 ± 0.07
1.97 ± 0.18
1.67 ± 0.07
1.73 ± 0.02
1.83 ± 0.12
Total protein (g/dL)
5.24 ± 0.19
6.11 ± 0.07
6.05 ± 0.11
6.63 ± 0.22
5.56 ± 0.14
6.29 ± 0.13
5.81 ± 0.08
Urea (g/L)
0.48 ± 0.04
0.49 ± 0.05
0.51 ± 0.05
0.56 ± 0.07
0.63 ± 0.02
0.61 ± 0.02
0.67 ± 0.04
Creatinine (mg/L)
6.6 ± 0.51
7 ± 0.63
6.2 ± 0.86
7.6 ± 0.51
6.6 ± 0.24
7.2 ± 0.58
7 ± 0.32
Sodium (mEq/L)
138.8 ± 1.28
139 ± 1.34
134 ± 1.91
138 ± 1.46
136.4 ± 1.36
137 ± 0.70
136.6 ± 0.98
Potassium (mEq/L)
4.1 ± 0.17
4.11 ± 0.17
4.19 ± 0.09
4.88 ± 0.24
3.82 ± 0.10
3.94 ± 0.12
4 ± 0.14
Chloride (mEq/L)
107 ± 2.10
109 ± 1.00
112.4 ± 1.25
112.2 ± 0.66
102.6 ± 0.68
106.2 ± 2.17
106.8 ± 1.39
The values are expressed as the mean ± SEM (n = 5). value was considered significant using ANOVA followed by Dunnett’s multiple comparison test. Asterisk denotes difference compared with the control group.
