Acute and Repeated Dose 28-Day Oral Toxicity Study of the Aqueous Extracts from the Leafy Stem and Fruit of Pedalium murex D.Royen EX.L in Wistar Rats
Table 8
Hematological parameters of rats after repeated treatment with aqueous extracts of P. murex leafy stem (LS) and fruit (FR).
Parameters
Control
LS 200
LS 400
LS 800
FR 200
FR 400
FR 800
RBC (T/L)
9.03 ± 0.33
8.54 ± 0.11
8.72 ± 0.12
8.04 ± 0.2
8.22 ± 0.24
8.73 ± 0.20
8.24 ± 0.14
HGB (g/dL)
14.78 ± 0.31
14.74 ± 0.1
15.76 ± 0.6
15.62 ± 0.25
13.4 ± 0.25
14.25 ± 0.44
13.63 ± 0.17
HCT (%)
47.41 ± 1.23
49.94 ± 0.95
47.6 ± 1.62
49.02 ± 0.96
42.92 ± 1.07
45.8 ± 1.49
43.15 ± 0.44
MCV (fL)
52.62 ± 0.85
58.52 ± 1.09
54.6 ± 1.28
61.14 ± 1.60
52.24 ± 0.40
52.27 ± 0.86
52.45 ± 1.08
MCH (g/dL)
16.24 ± 0.32
17.28 ± 0.15
18 ± 0.48
19.4 ± 0.35
16.32 ± 0.23
16.32 ± 0.28
16.58 ± 0.33
WBC (G/L)
18.98 ± 1.34
17.06 ± 1.33
16.72 ± 1.59
12.74±0.78
17.9 ± 2.23
13.73 ± 1.7
11.98±0.58
PLT (103/µL)
749 ± 91.28
937.6±55.66
509.8±52.30
545.8±43.69
770.4 ± 51.66
976.25±32.80
974.5±44.71
The values are expressed as the mean ± SEM (n = 5). value was considered significant using ANOVA followed by Dunnett’s multiple comparison test. Asterisk denotes difference compared with the control group.
