Acute and Subacute Toxicity of Rhamnus prinoides Leaves on Histopathology of Liver, Kidney, and Brain Tissues, and Biochemical Profile of Rats

Table 2

Food intake and weight gain of rats treated with leaf extract of R. prinoides.

Rats	Food intake and weight gain	Group
		Group I	Group II	Group III	Group IV
Male	Food intake (g/day) n = 5	110.2 ± 1.8	111.2 ± 2.4	113.8 ± 3.3	116.0 ± 2.9
	Weight gain/rat (g)	82.3 ± 4.6	98.0 ± 1.7	99.7 ± 1.7	86.3 ± 5.2
Female	Food intake (g/day) n = 5	88.8 ± 2.4	80.8 ± 2.3	84.1 ± 3.2	78.6 ± 2.2
	Weight gain/rat (g)	30.0 ± 5.0	34.7 ± 6.7	32.0 ± 2.1	23.3 ± 1.5

Results are expressed as mean ± SE; one-way ANOVA. Group I–III, respectively, received 250, 500, and 1000 mg/kg of R. prinoides extract and group IV: control.