Acute and Subacute Toxicity of Rhamnus prinoides Leaves on Histopathology of Liver, Kidney, and Brain Tissues, and Biochemical Profile of Rats

Table 4

Biochemical profile of male rats treated with leaf extract of R. prinoides.

Tests	Group
	Group I	Group II	Group III	Group IV
ALT (U/L)	40.01 ± 4.7	46.33 ± 5.2	55.01 ± 93.1	56.52 ± 3.5
AST (U/L)	193.22 ± 49.8	191.21 ± 7.8	216.82 ± 28.9	216.41 ± 23.5
ALP (U/L)	143.32 ± 24.3	154.01 ± 20.5	146.72 ± 12.2	162.74 ± 25.8
Urea (mg/dL)	43.05 ± 2.3	45.34 ± 2.6	43.86 ± 2.6	46.91 ± 1.9
Creatinine (mg/dL)	0.29 ± 0.06	0.33 ± 0.00	0.30 ± 0.01	0.31 ± 0.04
Albumin (g/dL)	4.49 ± 0.03	4.31 ± 0.04	4.55 ± 0.08	4.42 ± 0.09
Total protein (g/dL)	6.43 ± 0.28	6.07 ± 0.06	6.26 ± 0.09	6.26 ± 0.17
Total cholesterol (mg/dL)	51.42 ± 5.2	40.13 ± 1.2	40.15 ± 1.2	46.91 ± 1.7
Glucose (mg/dL)	121.33 ± 6.4	107.51 ± 19.3	80.54 ± 20.0	80.42 ± 6.6

Results are expressed as mean ± SE; one-way ANOVA. ALT: alanine aminotransferase, AST: aspartate aminotransferase, ALP: alkaline phosphatase. Group I–III, respectively, received 250, 500, and 1000 mg/kg of R. prinoides extract and group IV: control.