Acute and Subacute Toxicity of Rhamnus prinoides Leaves on Histopathology of Liver, Kidney, and Brain Tissues, and Biochemical Profile of Rats
Table 5
Biochemical profile of female rats treated with leaf extract of R. prinoides.
Tests
Groups
Group I
Group II
Group III
Group IV
ALT (U/L)
50.32 ± 2.5
48.51 ± 1.8
44.53 ± 0.8
49.51 ± 3.4
AST (U/L)
181.42 ± 28.7
183.70 ± 2.8
201.71 ± 4.9
194.90 ± 9.3
ALP (U/L)
89.01 ± 10.0
84.02 ± 6.7
85.71 ± 4.1
75.74 ± 9.8
Urea (mg/dL)
45.10 ± 2.6
45.81 ± 2.3
40.74 ± 0.7
40.71 ± 2.1
Creatinine (mg/dL)
0.35 ± 0.03
0.38 ± 0.02
0.31 ± 0.04
0.32 ± 0.03
Albumin (g/dL)
4.39 ± 0.15
4.33 ± 0.07
4.55 ± 0.08
4.37 ± 0.09
Total protein (g/dL)
6.43 ± 0.12
6.21 ± 0.02
6.43 ± 0.14
6.28 ± 0.15
Total cholesterol (mg/dL)
65.51 ± 0.67
68.21 ± 8.4
66.62 ± 3.6
65.94 ± 3.9
Glucose (mg/dL)
103.22 ± 2.6
101.31 ± 2.9
93.02 ± 1.2
93.10 ± 3.5
Results are expressed as mean ± SE; one-way ANOVA. ALT: alanine aminotransferase, AST: aspartate aminotransferase, ALP: alkaline phosphatase. Group I–III, respectively, received 250, 500, and 1000 mg/kg of R. prinoides extract and group IV: control.
