Imidacloprid Induces Neurotoxicity in Albino Male Rats by Inhibiting Acetylcholinesterase Activity, Altering Antioxidant Status, and Primary DNA Damage

Table 1

The effects of sublethal Imidacloprid doses on antioxidant parameters, lipid peroxidation, and neural biomarker (AChE) in rat brain tissues.

Treatment	AChE (ml mol/min/mg protein)	MDA (nmol/g tissues)	GSH (nmol/g tissues)	CAT (µmol/min/g tissues)	SOD (µmol/min/g tissues)
Control	3.75 ± 0.41	19.28 ± 2.79	21.37 ± 3.12	30.67 ± 2.08	11.76 ± 3.48
45 mg/kg IMI high dose	2.47 ± 0.41^a	29.79 ± 3.82^a	13.77 ± 1.58^a	22.56 ± 3.53^a	6.66 ± 1.65^a
22.5 mg/kg IMI low dose	2.75 ± 0.42^a	23.92 ± 1.18^a	17.63 ± 1.64^a	26.65 ± 1.4^a	7.23 ± 1.51^a

Data are expressed as mean ± SD (n = 5) ^aStatistical significance between imidacloprid treatment groups versus control group (the one-way ANOVA,  < 0.05).