Acute and Subchronic Oral Toxicity Evaluation of Herbal Formulation: <i>Piper crocatum</i> Ruiz and Pav., <i>Typhonium flagelliforme</i> (Lodd.) Blume, and <i>Phyllanthus niruri</i> L. in Sprague–Dawley Rats

<div>Hematoxylin and eosin-stained histological sections of the heart, kidney, lymph, liver, lung (200x magnification), stomach, and intestine (100x magnification) of the control rats and those exposed to 5000 mg/kg b.w. SKM acutely. No significant alteration was observed in all treatment groups. Cardiomyocyte bundle (C), mucosa (M), submucosa (SM), muscularis mucosa (MM), proximal tubules (P), distal tubules (D), glomerulus (G), white pulp (WP), red pulp (RP), trabeculae (T), sinusoid (S), central veins (CV), hepatocyte (H), alveolus (A), bronchiole (B), interalveolar septa (IS), and muscularis externa (ME).</div>

Journal of Toxicology

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Figure 3: Acute and Subchronic Oral Toxicity Evaluation of Herbal Formulation: <i>Piper crocatum</i> Ruiz and Pav., <i>Typhonium flagelliforme</i> (Lodd.) Blume, and <i>Phyllanthus niruri</i> L. in Sprague–Dawley Rats 

Figure 3 | Acute and Subchronic Oral Toxicity Evaluation of Herbal Formulation: Piper crocatum Ruiz and Pav., Typhonium flagelliforme (Lodd.) Blume, and Phyllanthus niruri L. in Sprague–Dawley Rats 