Acute and Subchronic Oral Toxicity Evaluation of Herbal Formulation: Piper crocatum Ruiz and Pav., Typhonium flagelliforme (Lodd.) Blume, and Phyllanthus niruri L. in Sprague–Dawley Rats
Table 6
Relative organ weight parameters of female SD rats fed exposed to SKM product (22.5; 45; 90 mg/kg b.w.) by oral route and control rats during the 90-day followed by a 28-day recovery period. Values are mean ± SE.
Organ
Relative organ weight (g) ± SE
Satellite relative organ weight (g) ± SE
Control (n = 7)
Group dose 22.5 mg/kg b.w. (n = 9)
Group dose 45 mg/kg b.w. (n = 7)
Group dose 90 mg/kg b.w. (n = 7)
Control (n = 5)
Group dose 90 mg/kg b.w. (n = 3)
Lung
0.010 ± 0.002
0.008 ± 0.001
0.006 ± 0.000∗
0.010 ± 0.002
0.007 ± 0.000
0.007 ± 0.001
Spleen
0.002 ± 0.000
0.002 ± 0.000
0.003 ± 0.000
0.003 ± 0.000
0.003 ± 0.001
0.004 ± 0.000
Stomach
0.006 ± 0.001
0.006 ± 0.000
0.006 ± 0.000
0.007 ± 0.000
0.007 ± 0.001
0.007 ± 0.001
Heart
0.003 ± 0.000
0.003 ± 0.000
0.003 ± 0.000
0.003 ± 0.000
0.003 ± 0.000
0.003 ± 0.000
Liver
0.020 ± 0.000
0.030 ± 0.000
0.030 ± 0.000
0.030 ± 0.000
0.030 ± 0.000
0.020 ± 0.000
Kidney
0.006 ± 0.000
0.006 ± 0.000
0.006 ± 0.000
0.006 ± 0.000
0.006 ± 0.000
0.006 ± 0.000
∗Significant differences compared to the control group.
