Assessment of Acute and Chronic Toxicity in Wistar Rats (Rattus norvegicus) and New Zealand Rabbits (Oryctolagus cuniculus) of an Enriched Polyphenol Extract Obtained from Caesalpinia spinosa
Table 1
Mean intake of food/water as well as initial and final body weight in rats and rabbits following 180 days of administration.
Animal
Sex
Group
N
Initial weight (g)
Final weight (g)
Body weight gain (g)
Food (g)
Water (mL)
Rats
Females
Test
5
195.33 ± 7.16
265.38 ± 17.17
68.12 ± 18.48
16.5 ± 3.9
29.2 ± 5.7
Control
5
191.69 ± 5.49
251.54 ± 20.60
59.85 ± 20.22
15.3 ± 2.0
26.1 ± 12.2
value
0.39
0.37
0.59
0.49
0.64
Males
Test
5
316.52 ± 18.54
545.90 ± 37.33
218.47 ± 30.56
24.0 ± 10.5
37.5 ± 4.2
Control
5
317.28 ± 18.85
510.10 ± 38.26
192.82 ± 25.92
28.0 ± 3.3
37.5 ± 4.2
value
0.95
0.24
0.25
0.51
0.60
Rabbits
Females
Test
5
2998 ± 94.12
5027 ± 631.30
2029 ± 537.19
163.5 ± 68.9
248.8 ± 158.5
Control
5
3258 ± 299.74
5848 ± 65.05
2590 ± 234.70
177 ± 33.9
260.0 ± 146.7
value
0.10
0.18
0.65
0.67
0.89
Males
Test
5
2903 ± 318.58
4221 ± 419.53
1317.40 ± 100.95
180.6 ± 48.6
324.3 ± 165.9
Control
5
2937 ± 221.26
4538 ± 292.40
1601.07 ± 71.14
140.8 ± 46.7
236.0 ± 137.0
value
0.85
0.32
0.73
0.19
0.35
N: number of animals in the group, data expressed as mean ± standard deviation. Body weight gain = initial weight–final weight. Number of animals per group at the end of the experiment: N = 2, N = 3, N = 4.
