Assessment of Acute and Chronic Toxicity in Wistar Rats (Rattus norvegicus) and New Zealand Rabbits (Oryctolagus cuniculus) of an Enriched Polyphenol Extract Obtained from Caesalpinia spinosa
Table 3
Effects of P2Et extract on biochemical parameters in rats following 180 days of administration.
Parameters (reference values)
Group
value
Test (N = 6)
Control (N = 8)
Kidney function
Urea (18.0 to 45.0 mg/dL)
47.30 ± 5.91
57.41 ± 6.29
0.01
Creatinine (0.05 to 0.65 mg/dL)
0.40 ± 0.09
0.38 ± 0.05
0.54
Sodium (135.0 to 146.0 mmol/L)
148.95 ± 8.82
153.99 ± 21.17
0.52
Potassium (4.0 to 5.9 mmol/L)
7.95 ± 2.20
6.16 ± 0.77
0.05
Chloride (96.0 to 107.0 mmol/L)
100.30 ± 1.11
99.76 ± 2.26
0.60
Calcium (5.3 to 11.6 mg/dL)
10.97 ± 0.93
10.28 ± 0.59
0.12
Liver function
ALT (20 to 61 U/L)
83.00 ± 39.59
95.13 ± 30.98
0.12
Phosphatase (16 to 302 U/L)
190.33 ± 55.32
249.75 ± 59.88
0.08
AST (39.0 to 111.0 U/L)
199.17 ± 153.83
213.88 ± 55.98
0.16
GGT (0 to 6 U/L)
5.00 ± 0.00
4.88 ± 0.35
0.70
Bilirubin (0.1 to 0.7 mg/dL)
0.17 ± 0.18
0.10 ± 0.00
0.61
Cholesterol (20 to 92 mg/dL)
53.00 ± 10.79
50.13 ± 6.06
0.70
Triglycerides (27 to 108 mg/dL)
164.60 ± 48.70
130.29 ± 52.37
0.24
N: number of animals in the group, data expressed as mean ± standard deviation. Statistically significant difference . ALT: alanine transaminase); AST: aspartate aminotransferase; GGT: gamma-glutamyl transferase.
