Assessment of Acute and Chronic Toxicity in Wistar Rats (Rattus norvegicus) and New Zealand Rabbits (Oryctolagus cuniculus) of an Enriched Polyphenol Extract Obtained from Caesalpinia spinosa
Table 5
Effects of P2Et extract on hematological parameters in rabbits following 180 days of administration.
Parameters and reference values
Group
value
Test (N = 7)
Control (N = 5)
Erythrogram
Erythrocytes (5.1 to 7.9 million/mm3)
6.07 ± 0.34
5.65 ± 0.39
0.08
Hemoglobin (10.0 to 17.4 g/dL)
13.34 ± 0.71
12.24 ± 0.52
0.02
Hematocrit (33.0 to 50.0%)
38.11 ± 2.24
36.18 ± 2.01
0.16
MVC (57.8 to 66.5 μ3)
62.80 ± 0.99
64.24 ± 5.37
0.87
MHC (17.1 to 23.5 pg)
21.99 ± 0.35
21.68 ± 1.06
0.49
MCHC (29.0 to 37.0 g/dL)
35.03 ± 0.43
33.86 ± 1.47
0.10
Leucogram
Leukocytes (5.2 to 12.5 thousands/mm3)
7.34 ± 1.64
6.18 ± 2.34
0.33
Neutrophil (20 to 75%)
56.29 ± 9.62
44.60 ± 8.62
0.06
Eosinophil (1 to 4%)
0.43 ± 0.53
1.40 ± 1.52
0.19
Lymphocytes (30 to 85%)
39.43 ± 9.36
52.40 ± 7.60
0.03
Monocytes (1 to 4%)
3.86 ± 3.08
1.60 ± 0.89
0.11
Coagulogram
PT (7.2 to 7.8 seconds)
6.29 ± 0.26
6.72 ± 0.65
0.14
Platelets (250 to 650 thousands/mm3)
382.71 ± 116.43
271.60 ± 36.79
0.05
PTT (35 seconds)
19.29 ± 1.95
16.86 ± 0.65
0.02
Total protein
5.4 to 8.5 g/dL
6.11 ± 0.28
6.12 ± 0.44
0.38
N: number of animals in the group, data expressed as mean ± standard deviation. Statistically significant difference . MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration (MCHC); PT: prothrombin time; PPT: partial thromboplastin time.
