Retinal Progenitor Cells Exhibit Cadherin-Dependent Chemotaxis across Transplantable Extracellular Matrix of In Vitro Developmental and Adult Models

Figure 1

Schematic of an adult mammalian retina. (A) The mature retina is composed of multiple cell layers (from right to left): retinal pigment epithelium (RPE), outer nuclear layer (containing rod and cone photoreceptors), inner nuclear layer (containing amacrine, bipolar, and horizontal cells), and the ganglion cell layer. (B) Image of outer nuclear layer gathered via transmitted electron microscopy (TEM) indicating where stem-like cells (SCs) are used as photoreceptor cell replacements. Image illustrates the photoreceptor inner segment, outer segment, and connecting cilia as marked (scale = 2 μm).