Development and Validation of a Multiparametric Semiquantitative Scoring System for the Histopathological Assessment of Ischaemia Severity in Skeletal Muscle
Table 2
Kendall’s W analysis reflecting interrater reliability assessment of histopathological features between three appraisers.
Histopathological parameters
% complete agreements (95% CI)
% agreement between 2 appraisals (95% CI)
% disagreement >2 scores (95% CI)
Kendall’s W
P value
Inflammation
44.3 (32.4, 56.6)
97.1 (90.1, 99.7)
5.7 (1.6, 14.0)
0.923
≤0.001
Fibrosis
51.4 (39.2, 63.6)
100 (94.9, 100)
0.0 (0.0, 5.1)
0.942
≤0.001
Necrosis
58.6 (46.2, 70.2)
98.6 (92.3, 100)
7.1 (2.3, 15.9)
0.771
≤0.001
Degeneration/regeneration
47.1 (35.1, 59.5)
94.3 (86.0, 98.4)
7.1 (2.3, 15.9)
0.863
≤0.001
Adipocyte infiltration
41.4 (29.8, 53.83)
98.6 (92.3, 100)
5.7 (1.6, 14.0)
0.914
≤0.001
CI: confidence interval; W: Kendall’s coefficient of concordance; all appraisers’ assessments agree with each other. values were calculated based on Kendall’s W scores from complete agreements.
