Human Bone Marrow versus Adipose-Derived Stem Cells: Influence of Donor Characteristics on Expandability and Implications for Osteogenic Ex Vivo BMP-2 Regional Gene Therapy

Table 3

Population doubling times.

	BMSC			ASC (TKA/AKS)			value
	N	Mean (days)	SD	N	Mean (days)	SD
P1 to P2	57	45.35	108.88	95	6.14	2.94	<0.001
P2 to P3	50	24.67	38.6	76	6.55	3.59	<0.001
P3 to P4	44	31.38	28.09	48	8.1	11.8	<0.001
P4 to P5	38	23.33	28.26	46	6.93	2.9	<0.001

ASC = adipose-derived stem cell, BMSC = bone marrow-derived stem cell, TKA = total knee arthroplasty, AKS = arthroscopic knee surgery, P1 = passage 1, P2 = passage 2, P3 = passage 3, P4 = passage 4, P5 = passage 5, and SD = standard deviation. Bold p values indicate significance.