Human Bone Marrow versus Adipose-Derived Stem Cells: Influence of Donor Characteristics on Expandability and Implications for Osteogenic Ex Vivo BMP-2 Regional Gene Therapy
Table 4
Comparison of good versus normal growth of BMSCs and ASCs.
PG
NG
value
Mean
SD
Mean
SD
ASC
N
10
95
Age
57.7
19.13
61.6
11.94
0.359
Sex
6 F, 4 M
47 F, 48 M
0.527
Tissue volume (mL)
8.1
3.57
10.78
5.21
0.116
Mono/SVF (×106 cells)
1.17
1.02
6.49
6.76
0.015
Cell yield/mL (×106 cells/mL)
0.16
0.15
0.61
0.53
0.009
BMI (kg/m2)
31.27
7.34
29.6
6.59
0.455
Serum albumin
4.05
0.36
4.3
0.29
0.056
HbA1c (%)
5.75
0.44
5.56
0.42
0.249
BMSC
N
8
43
Age
59.37
7.57
59.07
7.29
0.135
Sex
6 F, 2 M
19 F, 24 M
0.109
Tissue volume (mL)
54.38
51.92
58.84
47.73
0.812
Mono/SVF (×106 cells)
193.63
143.05
251.84
223.37
0.483
Cell yield/mL (×106 cells/mL)
5.69
3.98
8.51
13.78
0.572
BMI (kg/m2)
25.84
5.8
28.84
5.81
0.310
Serum albumin
4.49
0.32
4.32
0.34
0.241
HbA1c (%)
5.67
0.57
5.77
0.59
0.685
ASC = Adipose-derived stem cell, BMSC = bone marrow-derived stem cell, PG = poor growth, NG = normal growth, F = female, M = male, Mono = mononuclear cell count, SVF = stromal vascular fraction, BMI = body mass index, HbA1c = hemoglobin A1c, and SD = standard deviation. Bold p values indicate significance.
