Endothelial Cell-Derived Exosomes Inhibit Osteoblast Apoptosis and Steroid-Induced Necrosis of Femoral Head Progression by Activating the PI3K/Akt/Bcl-2 Pathway

<div>EC-exos facilitated the cell viability and migration of osteoblasts under Dex <i>in vitro</i>. (a) Scratch assay for evaluating the migration capacity of MC3T3-E1 cells at 0 and 24 h in different groups. Scale bar = 100 <i>μ</i>m. (b) Quantitative analysis of the migration area of MC3T3-E1 cells (<i>n</i> = 3). (c) The cell viability of different treatments on MC3T3-E1 cells were tested by CCK-8 assay. (d) The migration capacity of MC3T3-E1 cells was investigated by transwell assay in different groups. Scale bar = 100 <i>μ</i>m. 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Journal of Tissue Engineering and Regenerative Medicine

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Figure 2

Figure 2: Endothelial Cell-Derived Exosomes Inhibit Osteoblast Apoptosis and Steroid-Induced Necrosis of Femoral Head Progression by Activating the PI3K/Akt/Bcl-2 Pathway 

Figure 2 | Endothelial Cell-Derived Exosomes Inhibit Osteoblast Apoptosis and Steroid-Induced Necrosis of Femoral Head Progression by Activating the PI3K/Akt/Bcl-2 Pathway 