Endothelial Cell-Derived Exosomes Inhibit Osteoblast Apoptosis and Steroid-Induced Necrosis of Femoral Head Progression by Activating the PI3K/Akt/Bcl-2 Pathway

<div>The improvement effects of EC-exos on the rat model of SNFH. (a) Three plane images including coronal section (COR), sagittal section (SAG), and transverse section (TRA) of the femoral head were reconstructed in the different groups. (b–e) Quantitative analyses of bone volume per tissue volume (BV/TV), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), and trabecular number (Tb.N) in the different treatment groups (<i>n</i> = 3). (f) The effects of EC-exos on the rat model were evaluated by TUNEL assay. 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Journal of Tissue Engineering and Regenerative Medicine

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Figure 4

Figure 4: Endothelial Cell-Derived Exosomes Inhibit Osteoblast Apoptosis and Steroid-Induced Necrosis of Femoral Head Progression by Activating the PI3K/Akt/Bcl-2 Pathway 

Figure 4 | Endothelial Cell-Derived Exosomes Inhibit Osteoblast Apoptosis and Steroid-Induced Necrosis of Femoral Head Progression by Activating the PI3K/Akt/Bcl-2 Pathway 