Endothelial Cell-Derived Exosomes Inhibit Osteoblast Apoptosis and Steroid-Induced Necrosis of Femoral Head Progression by Activating the PI3K/Akt/Bcl-2 Pathway

<div>Verification of biological safety of EC-exos <i>in vivo</i>. (a) H&amp;E staining of heart, liver, lung, kidney, and spleen in rat model without treat or treating with EC-exos only. Scale bar = 100 <i>μ</i>m. (b) Blood routine index at week 6 (<i>n</i> = 3). (c) Prothrombin time at week 6 (<i>n</i> = 3). (d) Liver function indicators including alanine aminotransferase (ALT), aspartate transaminase (AST), albumin (ALB), and globulin (GLB) at week 6 (<i>n</i> = 3). (e) Kidney function indicators including creatinine (Cr) and blood urea nitrogen (BUN) at week 6 (<i>n</i> = 3).</div>

Journal of Tissue Engineering and Regenerative Medicine

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Figure 6

Figure 6: Endothelial Cell-Derived Exosomes Inhibit Osteoblast Apoptosis and Steroid-Induced Necrosis of Femoral Head Progression by Activating the PI3K/Akt/Bcl-2 Pathway 

Figure 6 | Endothelial Cell-Derived Exosomes Inhibit Osteoblast Apoptosis and Steroid-Induced Necrosis of Femoral Head Progression by Activating the PI3K/Akt/Bcl-2 Pathway 