Lack of Restoration in Vivo by K+-Channel Modulators of Jejunal Fluid Absorption after Heat Stable Escherichia coli Enterotoxin (STa) Challenge
Figure 2
The effect of intravenous perfusion by jugular vein of glibenclamide () at 7.0 mg/kg/hr, clotrimazole () at 2.85 mg/kg/hr, and cromakalim () at 2.72 mg/kg/hr on net fluid absorption from the proximal jejunum of the rat in vivo perfused luminally with 80 ng/mL E. coli STa heat stable enterotoxin. For comparison, fluid absorption without perfusion with STa () and with perfusion with STa () are given. Fluid absorption in the presence of STa was significantly lower () than control values. I.v. perfusion of the indicated potassium channel active agents in the presence of STa was not significantly different from STa perfusion alone.
