Research Article

Lack of Restoration in Vivo by K+-Channel Modulators of Jejunal Fluid Absorption after Heat Stable Escherichia coli Enterotoxin (STa) Challenge

Table 1

The pressor and depressor effects of clotrimazole (1 mg/kg i.v.), glibenclamide (1.5 mg/kg i.v.), and cromakalim (8–24 ug/kg i.v.) on the systolic, diastolic, pulse, and mean arterial blood pressure in the anaesthetised rat. Blood pressures are expressed as mm Hg tension. Results are expressed as means ± standard error of the mean with the number of observations in parenthesis or as differences in the means before and after intravenous drug administration. Statistical significance (a ; b ; c ) for comparison of parameters prior to and after drug administration.

Systolic pressure (mm Hg)Diastolic pressure (mm Hg)Pulse pressure (mm Hg)Mean arterial pressure (mm Hg)

Control (6) (6) (6) (6)
1 mg/kg clotrimazole (6)b (6)a (4) (6)a

Control (6) (6) (6) (6)
8 ug/kg cromakalim (3) (3) (3) (3)
16 ug/kg cromakalim (3) (3)c (3) (3)c
24 ug/kg cromakalim (3)a (3)a (3) (3)a

Control (7) (7) (7) (7)
1.5 mg/kg glibenclamide (7)c (7) (7) (7)