Visceral Leishmaniasis with Associated Common, Uncommon, and Atypical Morphological Features on Bone Marrow Aspirate Cytology in Nonendemic Region

Table 5

Comparison of hematological and bone marrow findings of the present study with previous studies in leishmaniasis.

	Bhatia et al. [3]; (% of cases)	Daneshbod et al. [4]; (% of cases)	Present study; (% of cases)
Peripheral blood smear
Pancytopenia	75	10	96.2
Anemia	—	70	100
Thrombocytopenia	—	30	100
Leucopenia	—	07	96.2
Monocytosis	62	—	18.5
Nucleated RBC	69	—	22.2
Bone marrow aspirate cytology
Distribution of LD bodies
Intrahistiocytic	44	—	00
Extrahistiocytic	31	—	3.7
Mixed	25	69	96.2
Plasmacytosis	56	77.9	96.2
Eosinophilia	—	27.4	14.8
Free cytoplasmic bodies
With LD bodies	—	31.3	3.7
Without LD bodies	—	75.4	14.8
Granular bodies	—	51.9	00
Erythroid hyperplasia	38	78.9	81.4
Increased histiocytes	81	—	100
Hemophagocytosis	75	6.8	70.3
Intracellular nonhistiocytic LD bodies	25	5.9	10.4
Plasma cells with abnormal inclusions	38	2.4	14.8
Increased blasts	06	01	—
Spore like organisms	—	11.8	—
Aggregates of LD bodies	56.2	15.7	11.1
Kinetoplast only	—	8.8	3.7
Pseudo-Pelger-Huet	25	4.9	00
Giant cells	—	7.8	3.7
Atypical histiocytes (Tart cell, foam cells, and RS cells)	25	25.4	00
Bone marrow biopsy
Necrosis	12	2.4	10.4
Granuloma	68	23	5.2
Increased fibrotic foci	19	4.4	10.4
Increased vascularity	63	5.9	31.5