Incidence and Predictors of Antiretroviral Treatment Modification in HIV-Infected Adults: A Brazilian Historical Cohort from 2001 to 2010

Table 3

Adjusted hazard ratio and 95% confidence interval (95% CI) estimated by Cox proportional hazards regression in multivariate analysis of the historical cohort for first ART modification, Belo Horizonte, Brazil.

Variables	aHR (95% CI)	value
Sex
Male	1.00
Female	1.62 (1.07–2.45)	0.022
AIDS- defining illness
No	1.00
Yes	1.49 (0.98–2.27)	0.061
First ART regimen prescribed
2 NRTI + NNRTI	1.00
2 NRTI + PI	2.70 (1.77–4.13)	<0.001

aHR: adjusted hazard ratio, ART: antiretroviral therapy, NRTI: nucleoside reverse transcriptase inhibitor, NNRTI: nonnucleoside reverse transcriptase inhibitor, and PI: protease inhibitor.
Multivariate analysis: Shoenfeld’s residual test: = 6.63; d.f. = 3; value = 0.452.