Review Article

Is Schistosomiasis a Risk Factor for Bladder Cancer? Evidence-Based Facts

Table 1

Histopathological review of bladder cancer and Schistosoma ova in sub-Saharan Africa.

StudyStudy method and objectivesFindings and conclusion

Botelho et al. 2015 (Angola) [7]One-year survey in Angola of 300 inhabitants to ascertain the prevalence of S. haematobiumThe prevalence of S. haematobium in this population was 71.7% with predominantly dysuria, hypogastric pain, and hematuria

Husain et al. 2008 (Sudan) [8]One-year retrospective study evaluating the risk factors of bladder tumor in Sudan84.6% of patients with SCC had a urinary schistosomiasis with Schistosoma egg seen on histology

Mapulanga et al. 2013 (Zambia) [9]A prospective cross-sectional study assessing the epidemiology, associated infection, and histology of bladder cancer60.4% of the histology was SCC, and of these, 43.8% has associated Schistosoma infection

Mungadi et al. 2007 (Nigeria) [10]5-year retrospective review of the epidemiology of bladder cancer in Northwestern NigeriaSCC accounted for 65.1% of all bladder tumors, and 50% of these cases had histological evidence of chronic urinary schistosomiasis

Mohammed et al. 2012 (Nigeria) [11]5-year histopathological review of Schistosoma infectionUrinary bladder schistosomiasis was the commonest site 62.6% with 30% associated bladder cancer

Rambau et al. 2013 (Tanzania) [12]10-year retrospective study to assess the burden of schistosomiasis and bladder cancerThe leading histological type was SCC (55.1%), and 73.5% of cases were associated with schistosomiasis

Diao et al. 2008 (Senegal) [13]Retrospective study of 428 patients assessing the epidemiological and histological profile of bladder cancer in SenegalThe leading histological type was SCC (50.7%), and 29.2% of cases had histological evidence of Schistosoma ova

Ibrahim et al. 2015 (Nigeria) [14]Retrospective study of 144 patients reviewing the clinical and histological pattern of bladder cancerThe commonest histological type was SCC (63.9%), and 41.7% of cases had histological evidence of Schistosoma ova

Ochicha et al. 2003 (Nigeria) [15]4-year retrospective study of 89 patients assessing the histological profile of bladder cancerThe commonest histological type was SCC (53.0%), and 21.3% of cases had histological evidence of Schistosoma ova