Journal of Tropical Medicine

Research Article

Antimalarial Activity of Aqueous and 80% Methanol Crude Seed Extracts and Solvent Fractions of Schinus molle Linnaeus (Anacardiaceae) in Plasmodium berghei-Infected Mice

Table 2

Body weight and rectal temperature changes of P. berghei-infected mice treated with the crude seed extracts and solvent fractions of S. molle.


Group	Weight (g)			Temperature (°C)
Group	D0	D4	Change	D0	D4	Change

80ME100	28.50 ± 0.63	26.47 ± 0.68	−2.03 ± 0.17	36.70 ± 0.35	35.50 ± 0.36	−1.20 ± 0.02
80ME200	28.66 ± 0.66	27.53 ± 0.69	−1.13 ± 0.13	37.05 ± 0.32	36.52 ± 0.32	−0.53 ± 0.01
80ME400	28.63 ± 0.66	28.42 ± 0.66	−0.21 ± 0.017	36.94 ± 0.27	36.70 ± 0.27	−0.24 ± 0.01
CON	28.17 ± 0.82	24.54 ± 0.50	−3.63 ± 1.46	36.85 ± 0.22	34.47 ± 0.27	−2.38 ± 0.06
CQ10	28.52 ± 0.79	28.80 ± 0.83	0.28 ±	37.20 ± 0.22	38.00 ± 0.21	0.80 ± 0.03

AE100	28.14 ± 0.77	24.68 ± 0.77	−3.46 ± 0.64	37.15 ± 0.44	34.78 ± 0.43	−2.37 ± 0.01^c∗d∗e∗
AE200	28.35 ± 0.55	24.89 ± 0.55	−3.45 ± 0.01	36.88 ± 0.22	34.54 ± 0.24	−2.34 ± 0.00^{a∗b∗d∗e∗}
AE400	28.54 ± 0.86	25.38 ± 0.84	−3.16 ± 0.04	36.97 ± 0.30	35.12 ± 0.29	−1.85 ± 0.01
CON	28.22 ± 0.85	24.74 ± 0.88	−3.48 ± 0.10	37.05 ± 0.42	34.69 ± 0.41	−2.36 ± 0.04
CQ10	28.23 ± 0.50	28.45 ± 0.46	0.22 ± 0.057	36.99 ± 0.28	37.67 ± 0.27	0.68 ± 0.04

CF100	28.44 ± 0.80	26.15 ± 0.79	−2.29 ± 0.01	36.95 ± 0.16	35.29 ± 0.15	−1.66 ± 0.01
CF200	28.05 ± 0.68	26.63 ± 0.69	−1.42 ± 0.02	36.99 ± 0.29	36.15 ± 0.30	−0.84 ± 0.00
CF400	28.18 ± 0.64	27.64 ± 0.63	−0.54 ± 0.01	36.89 ± 0.29	36.39 ± 0.27	−0.50 ± 0.01
CON	28.41 ± 0.86	24.82 ± 0.57	−3.59 ± 0.85	36.81 ± 0.35	34.48 ± 0.32	−2.33 ± 0.06
CQ10	28.59 ± 0.88	28.83 ± 0.86	0.24 ± 0.04	37.02 ± 0.32	37.71 ± 0.29	0.70 ± 0.05

BF100	28.28 ± 0.39	24.90 ± 0.66	−3.39 ± 0.08	37.02 ± 0.67	35.04 ± 0.66	−1.98 ± 0.09
BF200	29.12 ± 0.66	26.47 ± 0.67	−2.65 ± 0.02	36.87 ± 0.66	35.74 ± 0.67	−1.14 ± 0.01
BF400	28.08 ± 0.69	26.65 ± 0.70	−1.43 ± 0.01	37.01 ± 0.69	36.26 ± 0.70	−0.75 ± 0.01
CON	27.93 ± 0.81	24.28 ± 0.79	−3.65 ± 0.09	36.97 ± 0.81	34.66 ± 0.80	−2.31 ± 0.08
CQ10	28.24 ± 0.61	28.43 ± 0.60	0.19 ± .03	36.92 ± 0.62	37.54 ± 0.60	0.62 ± 0.05

AF100	28.33 ± 0.68	24.72 ± 0.67	−3.62	36.98 ± 0.26	34.66 ± 0.26	−2.32 ± 0.01
AF200	28.34 ± 0.57	24.75 ± 0.56	−3.59	36.96 ± 0.26	34.61 ± 0.27	−2.35 ± 0.02
AF400	28.05 ± 0.79	24.82 ± 0.77	−3.2301	37.04 ± 0.25	34.79 ± 0.24	−2.25 ± 0.01
CON	28.51 ± 0.75	24.86 ± 0.81	−3.65	37.05 ± 0.27	34.72 ± 0.34	−2.33 ± 0.10
CQ10	28.45 ± 0.67	28.68 ± 0.68	0.22	36.89 ± 0.22	37.56 ± 0.21	0.67 ± 0.06

Data are expressed as mean ± SEM (n = 6); ^acompared to CON; ^bcompared to 100 mg/kg; ^ccompared to 200 mg/kg; ^dcompared to 400 mg/kg; ^ecompared to CQ10; and. D0 = pretreatment value on day 0, D4 = posttreatment value on day four. AE = aqueous crude extract, 80ME = 80% methanol crude extract, CF = chloroform fraction, BF = butanol fraction, AF = aqueous fraction, CON = control, and CQ = chloroquine base. Numbers after letters in the first column refer to dose in mg/kg.