In Vitro Antiplasmodial, Heme Polymerization, and Cytotoxicity of Hydroxyxanthone Derivatives

Table 4

The IC₅₀ values of hydroxyxanthone compounds on Vero cell after 24 hours incubation using the MTT assay method.

Compounds	Concentration (μM)	Vero cell growth inhibition (%) after 24 hours incubation	IC50 (µM)
HX1	8190.01	89.43 ± 1.90	3394.90 ± 435.44
	4095.00	45.86 ± 5.51
	2047.50	27.96 ± 5.69
	1023.75	15.89 ± 8.24
	511.88	−4.13 ± 8.21
	255.94	−50.32 ± 17.18
HX2	1734.91	86.09	308.32
	867.45	67.03
	433.73	59.75
	216.86	38.93
	108.26	31.75
	54.13	15.63
HX3	2047.50	88.86	224.45
	1023.75	79.92
	511.88	68.04
	255.94	55.70
	127.76	39.58
	63.88	20.70
HX4	2027.14	89.96	330.68
	1013.57	68.87
	506.78	54.41
	253.39	43.17
	126.49	32.49
	63.25	19.04
HX5	2064.07	88.76	417.57
	1032.03	68.13
	516.02	48.33
	258.01	37.83
	128.80	27.88
	64.40	−5.19