Effect of Isoniazid Preventive Therapy on the Incidence of Tuberculosis among Seropositive Children Attending HIV/AIDS Care in Two General Hospitals, Northwest Ethiopia, 2021

Table 4

Bi-variate and multivariate Cox regressions for incident of tuberculosis among seropositive children in two hospitals of Northwest Ethiopia from 2015–2020 (N = 421).

Variables		TB case	Censored	IPT group	Non-IPT	CHR = 95% CI	AHR = 95% CI	< 0.05
Sex	Male	30	174	123	81	1.39 (0.745–2.248	1.2 (0.618–2.53)	0.53
	Female	22	192	130	87	1	1	—
Age of children	< =5 years	2	85	60	34	1	1	—
	6–10 years	12	134	94	71	3.23 (1.24–8.42)	2.214 (0.8–5.9)	0.134
	≥11 years	50	138	99	63	2.8 (1.05–7.49)	4.2 (1.04–7.0)	0.04
Isoniazid (IPT)	Yes	15	243	253	—	1	1	—
	No	49	114	—	168	10.47 (4.68–23.1)	8.567 (3.5–21.5)	0.01
Cotrimoxazole (CPT)	Yes	28	293	198	55	1	1	—
	No	36	64	118	50	3.97 (2.25–6.7)	2.2 (1.11–3.7)	0.022
TB history of contact	Yes	53	82	83	96	2.8 (1.63–4.93)	1.4 (0.75–2.9)	0.26
	No	11	275	72	170	1	1	—
CD4 count	< 100	6	24	16	14	3.99 (1.6–9.77)	3.96 (1.5–10.3)	0.005
	101–200	21	53	38	36	4.67 (2.6–8.57)	1.74 (0.86–3.4)	0.12
	≥200	25	293	199	118	1	1	—
Weight for age (WFA)	Normal	35	249	180	116	1	1	—
	Moderate stunting	21	83	59	38	1.64 (0.95–2.82)	1.3 (0.6–2.71)	0.113
	Severe stunting	8	25	14	14	1.93 (0.89–4.1)	2.4 (0.80–7.3)	0.72
WHO	Stages 1 and 2	14	255	180	89	1	—	—
	Stages 3 and 4	50	102	73	79	5.70 (3.1–10.4)	1.44 (1.06–3.3)	0.032
Hemoglobin	>10 mg/dl	12	251	188	86	1	1
	≤ 10 mg/dl	52	106	65	82	3.02 (2.18–4.77)	0.91 (0.42–1.9)	0.31
MUAC	>11.5 cm	12	261	179	74	1	1	—
	≤ 11.5 cm	40	108	74	94	7.9 (4.14–15.09)	4.436 (1.99–9.97)	0.001